What question did this study set out to answer?

To characterize the clinical presentation, histologic grading, c-KIT mutation status, and long-term outcomes of cutaneous mastocytosis in young dogs.

May 24, 2023Veterinary PathologyOpen Access

Cutaneous mastocytosis in 8 young dogs and review of literature

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Authors

CYChing YangLong Island University CBCharles W. BradleyUniversity of Pennsylvania DPDiane E. PreziosiAlaska Neurology Center

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Implication

Case series reveals variable clinical outcomes and absence of c-KIT mutations in young dogs with cutaneous mastocytosis, indicating standard grading systems do not reliably predict prognosis.

Key Points

To characterize the clinical presentation, histologic grading, c-KIT mutation status, and long-term outcomes of cutaneous mastocytosis in young dogs.
Reviewed standardized survey and clinical data from 8 young dogs presenting with cutaneous mastocytosis onset at less than 1.5 years of age and more than 3 cutaneous lesions.
Evaluated biopsy specimens via Patnaik and Kiupel histologic grading schemes and performed mutation analysis on c-KIT exons 8 and 11.
All 8 dogs lacked c-KIT exon 8 and 11 mutations; 6 dogs had low-grade/grade II neoplasms and 2 dogs had high-grade/grade II neoplasms.
Medical management included antihistamines (8/8), corticosteroids (7/8), lokivetmab (3/8), and toceranib (1/8).
At a median follow-up of 898 days, 6 dogs remained alive with lesions, while 2 dogs were euthanized at 56 days and 621 days post-diagnosis.

Cite This Study

Yang et al. (2023) studied this question.

synapsesocial.com/papers/6ab494cde0e61119936d86c8 https://doi.org/10.1177/03009858231174452

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Implication

Case series reveals variable clinical outcomes and absence of c-KIT mutations in young dogs with cutaneous mastocytosis, indicating standard grading systems do not reliably predict prognosis.

Cutaneous mastocytosis in 8 young dogs and review of literature

Discussion

Member takes

Implication

Key Points

Cite This Study

Cutaneous mastocytosis in 8 young dogs and review of literature

Discussion

Member takes

Implication

Key Points

Cite This Study

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