Lesion pathology predicts response to plasma exchange in secondary progressive MS

Plasma exchange has been evaluated for treatment of acute inflammatory demyelinating syndromes of the CNS, e.g., acute relapsing multiple sclerosis (MS).1–3 It was recently reported that the pathologic pattern type II4 predicts the response to plasmapheresis treatment.5 Notably, however, these investigators had studied patients with fulminant attacks of MS. In a commentary,6 these findings were put in the context of older studies on the utility of plasma exchange in MS. Here, we report on a 32-year-old woman with a >6-year history of MS who had entered the chronic progressive phase 17 months before starting plasma exchange therapy. Prior to this, the patient had …