Neuroradiological findings in hereditary spastic paraplegia with a thin corpus callosum

Neuroradiological findings in hereditary spastic paraplegia with a thin corpus callosumWe read with interest the recent, excellent article by Okubo et al. (1) who described the case of a 25-yearold man suffering from hereditary spastic paraplegia with a thin corpus callosum (HSP-TCC).In their article, the authors reported that cerebral blood flow (CBF) in the thalamus showed further reduction without progression to other involved regions during the follow-up period.We, too, have experienced a Japanese male patient suffering from HSP-TCC who was followed-up with 123 I-IMP SPECT over a period of 2 years (from 25 to 27 years of age).Our case, in contrast to the above authors', showed a decrease in CBF in the cerebral cortex without progression in the thalamic region during the follow-up period.At the age of 25, the patient could walk alone without assistance, although he showed spastic gait, and MR imaging showed an extremely thin corpus callosum.Also, mild cortical atrophy was present for his age.SPECT at that time demonstrate decreased CBF in the thalamic area but no apparent reduction in the cerebral cortex.Over a period of 2 years, the patient slowly developed gait disturbance due to spastic paraplegia, and was eventually unable