miR‐126‐3p Inhibits Microglial M1 Polarization via the AKT2/NF‐ κ B Pathway to Alleviate Migraine Pain

Background and Objectives Migraine is a debilitating neurological disorder characterized by severe headache and neuroinflammation. This study investigates the role of miR‐126‐3p in regulating microglial M2 polarization via the AKT2/NF‐ κ B pathway to alleviate migraine pain. Methods We employed the mouse model of migraine induced by nitroglycerin (NTG) and the BV‐2 microglial cell model stimulated by lipopolysaccharide (LPS) to examine how miR‐126‐3p affects microglia and alleviates migraine pain. Results Our findings indicate that miR‐126‐3p promotes the transformation of microglia from the M1 type to the M2 type by inhibiting the AKT2/NF‐ κ B pathway, thereby reducing the expression of proinflammatory factors. This alleviation of neuroinflammation alleviates the neural pain associated with migraine. Conclusions miR‐126‐3p regulates the polarization morphology of microglia through the AKT2/NF‐ κ B pathway and plays a crucial role in modulating neuroinflammation in migraine. This discovery may pave the way for developing improved therapeutic strategies to manage migraine pain.