September 12, 2025Journal of Clinical MedicineOpen Access

miR-197, miR-101, and miR-143 and Pro-Inflammatory Cytokines in Migraine

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Discussion

Observational analysis found elevated microRNAs and cytokines in migraine patients, suggesting inflammation's role in symptoms.

Inflammation is a key factor in migraine, particularly in chronic migraine patients compared to episodic ones.
Cytokines IL-17 and IL-6 were significantly elevated in chronic migraine patients, suggesting a link to inflammation.
hsa-miR-197-3p levels were higher in patients without aura, indicating its potential role in migraine pathophysiology.
The study used qPCR and ELISA methods to analyze microRNAs and cytokine levels in migraine patients and controls.

Gómez et al. (2025) studied this question.

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