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December 8, 2025Cephalalgia

miR-382-5p and miR-34a in migraine: Expression in monocytes and a post-hoc exploratory comparison with expression in peripheral blood mononuclear cells

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Authors

RGRosaria GrecoFBFederico BighianiAZAnnamaria Zanaboni

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Overview

Cross-sectional analysis highlights miR-34a and miR-382-5p changes in monocytes among migraine types, suggesting possible epigenetic roles.

Key Points

  • miR-34a and miR-382-5p are significantly higher in monocytes from migraine patients compared to healthy controls.
  • Higher expression shown in episodic and chronic migraine with medication overuse individuals, indicating severity-associated differences.
  • Assessment utilized qRT-PCR for quantifying miRNA expression, normalized with U6 RNA, ensuring accurate comparison.
  • Findings underline potential epigenetic mechanisms at play in migraine pathophysiology, warranting further exploration.

Cite This Study

Greco et al. (2025) studied this question.

synapsesocial.com/papers/693624ba4fa91c937236ca68https://doi.org/10.1177/03331024251386769
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Also Consider

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  1. 1miR-197, miR-101, and miR-143 and Pro-Inflammatory Cytokines in Migraine2025
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  5. 5Bioinformatic Analysis from a Descriptive Profile of miRNAs in Chronic Migraine2024 · 1 citations