Key result
Insulin-mediated capillary recruitment is impaired in insulin-resistant states with little or no change to the exercise response, suggesting a microvascular mechanism for insulin resistance.
The review highlights that impaired insulin-mediated capillary recruitment may contribute to the vascular and metabolic defects seen in insulin resistance.
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May link microvascular dysfunction to insulin resistance; leaves open whether restoring recruitment improves metabolic outcomes.
The evidence that muscle metabolism is determined by available capillary surface area is examined. From newly developed methods it is clear that exercise and insulin mediate capillary recruitment as part of their actions in vivo. In all insulin-resistant states examined thus far, insulin-mediated capillary recruitment is impaired with little or no change to the exercise response. Control mechanisms for capillary recruitment for exercise and insulin are considered, and the failure of the microvasculature to respond to insulin is examined for possible mechanisms that might account for impaired vascular responses to insulin in insulin resistance.
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Rattigan et al. (2006) conducted a review in Insulin resistance. Insulin and exercise was evaluated. Insulin-mediated capillary recruitment is impaired in insulin-resistant states with little or no change to the exercise response, suggesting a microvascular mechanism for insulin resistance.
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