Prevalence and Incidence of Depression during Interferon-Based Antiviral Therapy in Chronic Hepatitis C Patients in the Republic of Korea

Figures

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  Fig. 1. Development of depression during antiviral treatment. Depressive symptoms developed in 34.6% (n=18) with a BDI-I score ≥10 (A) and 29.5% (n=18) with a HADS-D score ≥8 (B) among 52 and 61 patients who had no depression at baseline, respectively. The point prevalence of moderate to severe depression (BDI-I score ≥16 and HADS-D ≥11) was 17.3% (n=9) according to the BDI-I score and 9.8% (n=6) according to the HADS-D score over the course of pegylated interferon and RBV therapy. The majority of patients exhibited increased BDI-I or HADS-D scores during treatment, which returned to normal after the completion of treatment. BDI-I, Beck Depression Inventory-I; HADS-D, Hospital Anxiety and Depression scale-Depression.

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  Fig. 2. Cumulative incidence of depression during antiviral treatment with pegylated interferon α and ribavirin. The cumulative incidence rates of depression during antiviral therapy were 21.5% versus 21.5% at 12 weeks, 30.4% versus 27.2% at 24 weeks, 38.3% versus 34.2% at 36 weeks according to BDI-I (A) versus HADS-D (B), respectively. BDI-I, Beck Depression Inventory-I; HADS-D, Hospital Anxiety and Depression scale-Depression; FU, follow-up; Pt., patients.

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  Fig. 3. Changes in the Beck Depression Inventory-I (BDI-I) score during pegylated interferon and ribavirin therapy among patients with underlying depression at baseline. Seven patients with pretreatment depression showed aggravation of the BDI-I score during antiviral therapy, and two patients (number 2 and number 10) received antidepressant therapy. Moreover, one patient did not recover after 6 months from the end of pegylated interferon α and ribavirin therapy.