Why the study?
What are the baseline and on-treatment predictors of depression in chronic hepatitis C patients receiving peginterferon and ribavirin?
Population
n=201 prior nonresponders with advanced fibrosis and chronic hepatitis C
Design
Cohort
Follow-up
up to 72 weeks
Authors
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May flag higher depression risk in virological non-responders; hypothesis-generating and requires prospective validation before guiding hepatitis C care.
What are the baseline and on-treatment predictors of depression in chronic hepatitis C patients receiving peginterferon and ribavirin?
In patients with chronic hepatitis C treated with peginterferon and ribavirin, the absence of a virological response at week 20 independently predicted the development of interferon-induced depression.
Fontana et al. (2008) studied this question.
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