Why the study?
Does peginterferon alfa-2a and ribavirin retreatment worsen cognitive function in patients with chronic hepatitis C?
Population
177 patients with chronic hepatitis C who were prior nonresponders to interferon
Design
Cohort
Follow-up
72 weeks
Authors
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Stable objective cognition during retreatment; leaves open symptom origins and requires randomized confirmation.
Does peginterferon alfa-2a and ribavirin retreatment worsen cognitive function in patients with chronic hepatitis C?
Retreatment with peginterferon and ribavirin in chronic hepatitis C patients does not cause objective cognitive impairment, suggesting self-reported cognitive symptoms are likely related to systemic and psychiatric side effects.
Fontana et al. (2007) studied this question.
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