Key result
Generalized insulin-induced edema developed in a 24-year-old man with type 3c diabetes following rapid insulin intensification, which completely resolved after three weeks of diuretic therapy.
Case Report (n=1)
No
Insulin edema is a rare but reversible complication of insulin therapy initiation and intensification that can occur in Type 3c diabetes and is manageable with diuretics.
Highlights potential diuretic management of insulin edema in Type 3c diabetes; single case leaves open broader confirmation.
Insulin edema is a rare complication of insulin therapy that can occur after the initiation and intensification of insulin commonly seen in Type 1 Diabetes with chronic hyperglycemia. Here, we report the occurrence of generalized edema in a 24-year-old man with Type 3 c (Pancreatogenic) diabetes due to chronic pancreatitis, early after the initiation and self- intensification of insulin. Various differentials were excluded, and resolution of edema was achieved after 3 weeks with diuretics. The incidence of Insulin edema being a rare occurrence and as a diagnosis of exclusion we present this case to increase awareness as it carries a good prognosis. We reviewed the current literature and the possible mechanisms behind this phenomenon.
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Neil et al. (2023) conducted a case report in Type 3c (Pancreatogenic) Diabetes (n=1). Insulin therapy was evaluated on Resolution of edema. Generalized insulin-induced edema developed in a 24-year-old man with type 3c diabetes following rapid insulin intensification, which completely resolved after three weeks of diuretic therapy.
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