Key result
Insulin therapy triggers massive transient fluid retention in newly diagnosed T1D.
Why the study?
Insulin oedema is a rare complication of insulin therapy with variable presentations, and detailed case descriptions are limited.
Case Report (n=1)
Insulin oedema is a rare complication of insulin therapy in Type 1 diabetes that can present with massive serosal effusions and peripheral oedema, mimicking cardiac failure.
Answers are grounded in this paper and cite their sources.
Recognize insulin oedema to avoid misdiagnosing fluid retention as cardiac failure; this case leaves open its true incidence in Type 1 diabetes.
Insulin oedema is a rare complication of insulin therapy and usually occurs in patients with Type 1 diabetes. It can present in a variety of ways, from mild peripheral oedema to cardiac failure and massive serosal effusions. We report a 19-year-old woman with newly diagnosed Type 1 diabetes who presented with bilateral pleural effusions, ascites and extensive peripheral oedema 2 weeks after starting insulin therapy. Significant cardiac disease was excluded, and the massive fluid retention resolved spontaneously with conservative management. A review of the literature is presented.
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Lee et al. (2007) conducted a case report in Type 1 diabetes / Insulin oedema (n=1). Insulin lispro and detemir was evaluated. Insulin therapy (lispro and detemir) in a 19-year-old woman with newly diagnosed Type 1 diabetes resulted in massive fluid retention that resolved spontaneously with conservative management.
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