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Two patients had jaundice during treatment with oral contraceptives. One of them had a history of idiopathic jaundice of pregnancy. The laboratory data included elevated levels of serum transaminase and alkaline phosphatase, and increased sulfobromophthalein (Bromsulphthalein) retention. Optical microscopy of the livers revealed intrahepatic cholestasis and slight hepatocellular damage. Electron microscopy showed cholestasis and hepato-cellular damage. Similar cases have been reported in the literature.
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Ulf Larsson‐Cohn (1965) studied this question.
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