Key result
GDNF induced a biphasic growth stimulatory effect in human adult mesangial cells at 2 ng/ml and dose-dependently increased cellular protein and extracellular matrix synthesis.
GDNF and its receptors are expressed in the adult human kidney, and GDNF acts as a growth factor for mesangial cells, suggesting a potential role in the pathogenesis of glomerulosclerosis.
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GDNF may promote mesangial expansion in vitro; leaves open its role in human glomerulosclerosis pathogenesis.
Orth et al. (2000) studied Glomerulosclerosis. Glial cell line-derived neurotrophic factor (GDNF) was evaluated on HMC growth (cellular protein synthesis, DNA synthesis, cell proliferation, extracellular matrix synthesis). GDNF induced a biphasic growth stimulatory effect in human adult mesangial cells at 2 ng/ml and dose-dependently increased cellular protein and extracellular matrix synthesis.
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