Key result
Elevated baseline WBC >7,000 is linked to ~22% higher all-cause mortality in LV dysfunction.
Why the study?
The predictive value of baseline white blood cell count on mortality in patients with ischemic and nonischemic left ventricular systolic dysfunction was unclear.
Does a baseline WBC count >7,000 predict increased mortality in patients with left ventricular systolic dysfunction?
Population
Patients with ischemic and nonischemic left ventricular systolic dysfunction from the SOLVD trials
Comparison
Baseline WBC count >7,000 vs baseline WBC count ≤7,000
Design
Retrospective analysis of cohort data from SOLVD trials
Authors
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May enhance risk stratification in LV dysfunction; hypothesis-generating and requires prospective validation before clinical use.
Cohort
Does a baseline WBC count >7,000 predict increased mortality in patients with left ventricular systolic dysfunction?
Relative Risk: 1.22
Absolute Event Rate: 27% vs 21%
p-value: p=0.001
An elevated baseline white blood cell count is an independent predictor of all-cause mortality in patients with ischemic left ventricular dysfunction.
Cooper et al. (1999) conducted a cohort in Left ventricular systolic dysfunction. Baseline white blood cell (WBC) count >7,000 vs. Baseline WBC count ≤7,000 was evaluated on All-cause mortality (RR 1.22, p=0.001). A baseline white blood cell count >7,000 was significantly associated with increased all-cause mortality compared to ≤7,000 in patients with left ventricular dysfunction (27% vs 21%; RR 1.22, P=0.001).
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