The nature of the beaded filaments in the lens fiber cell has been debated for some time. One explanation is that beaded filaments represent an association of alpha-crystallin with actin filaments. By using a double labelling technique that allowed us to view actin filaments and alpha-crystallin in the same cell we have demonstrated that some of the alpha-crystallin in lens cells is indeed associated with actin.
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Vecchio et al. (1984) studied this question.
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