What question did this study set out to answer?

To compare two ovarian stimulation protocols combining gonadotrophins with D-Trp6-LHRH microcapsules for pituitary suppression in women undergoing in-vitro fertilization.

February 1, 1988Human Reproduction

Ovarian stimulation for in-vitro fertilization combining administration of gonadotrophins and blockade of the pituitary with D-Trp6-LHRH microcapsules: pilot studies with two protocols

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To compare two ovarian stimulation protocols combining gonadotrophins with D-Trp6-LHRH microcapsules for pituitary suppression in women undergoing in-vitro fertilization.
Evaluated 408 IVF cycles stimulated with human menopausal gonadotrophin (HMG) or FSH plus HMG combined with a single injection of D-Trp6-LHRH microcapsules.
Assigned patients to protocol 1 (blocking protocol, n = 268; 3.75 mg full dose prior to stimulation until E2 < 50 pg/ml) or protocol 2 (flare-up protocol, n = 140; 1.80 mg half dose initiated concurrently with gonadotrophins).
Gonadotrophin consumption was lower in protocol 2 (20 ± 9 ampoules) compared to protocol 1 (39.5 ± 11.2 ampoules).
In patients with purely tubal infertility under 38 years old without male factor, pregnancy rates per cycle were 22.6% in protocol 1 versus 20.5% in protocol 2.
Pregnancy rates per embryo transfer in the same subgroup were 28.3% in protocol 1 versus 27.4% in protocol 2.

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Implication

Pilot study reveals comparable pregnancy rates with lower gonadotrophin requirements using a flare-up protocol in IVF patients, suggesting improved cost-effectiveness.

Cite This Study

Zorn et al. (1988) studied this question.

synapsesocial.com/papers/6ab4a62811a27dcc996144cd https://doi.org/10.1093/oxfordjournals.humrep.a136684

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Implication

Pilot study reveals comparable pregnancy rates with lower gonadotrophin requirements using a flare-up protocol in IVF patients, suggesting improved cost-effectiveness.

Ovarian stimulation for in-vitro fertilization combining administration of gonadotrophins and blockade of the pituitary with D-Trp6-LHRH microcapsules: pilot studies with two protocols

Key Points

Discussion

Implication

Cite This Study

Ovarian stimulation for in-vitro fertilization combining administration of gonadotrophins and blockade of the pituitary with D-Trp6-LHRH microcapsules: pilot studies with two protocols

Key Points

Discussion

Implication

Cite This Study

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