Key result
The authors argue that the EMA's recommendation to suspend hydroxyethyl starch is scientifically unjustified because the cited trials evaluated its use outside of proper indications.
Why the study?
Does hydroxyethyl starch compared to crystalloids cause harm when used for fluid resuscitation in critically ill patients?
Population
Patients with intravascular hypovolemia, including septic and ICU patients
Comparison
Hydroxyethyl starch (HES) for fluid resuscitation vs Crystalloids
Design
Editorial
Authors
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This editorial challenges the EMA's suspension of hydroxyethyl starch, arguing that the trials demonstrating harm used the colloid inappropriately during the maintenance rather than resuscitation phase.
Does hydroxyethyl starch compared to crystalloids cause harm when used for fluid resuscitation in critically ill patients?
This editorial challenges the EMA's suspension of hydroxyethyl starch, arguing that the trials demonstrating harm used the colloid inappropriately during the maintenance rather than resuscitation phase.
Chappell et al. (2013) conducted an editorial in Sepsis and intravascular hypovolemia. Hydroxyethyl starch (HES) vs. Crystalloids was evaluated. The authors argue that the EMA's recommendation to suspend hydroxyethyl starch is scientifically unjustified because the cited trials evaluated its use outside of proper indications.
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