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A folic acid targeted anticancer drug delivery system based on Pt (IV) complexes pro-drug conjugated up- conversion NaYF4:Yb3+/Er3+ nanoparticles has been developed. The platinum (IV) complexes as pro-drugs can exhibit anti-cancer activities when the platinum (IV) complexes are reduced to platinum (II) in the intracellular environment. Meanwhile, the drug delivery system can be used as a luminescent probe for up-conversion cell imaging.
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Dai et al. (2012) studied this question.
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