Over the past decade, insights into the origins and behavior of human cancers have reshaped our understanding of these diseases and have generated advances in clinical care. The seminal feature of this research is the focus on human cancers. By using ideas and technologies originally derived from basic science laboratories, investigators have shifted the forefront of cancer research from in vitro models of tumor growth to the characterization and treatment of cancers in humans.This issue of the Journal launches a series of reviews on the molecular origins of cancer. The goal of this series is to highlight advances in . . .
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Burstein et al. (2008) studied this question.