Key result
In an animal model of massive rivaroxaban overdose, administration of procoagulants like PCC and rFVIIa partially corrected coagulation test results but did not reduce clinical bleeding.
Why the study?
Does rFVIIa or PCC reduce bleeding or normalize coagulation tests in a rabbit model of rivaroxaban overdose?
Population
Rabbits subjected to a standardized liver and spleen incision after receiving high-dose intravenous…
Comparison
Activated recombinant factor VII or prothrombin… vs Saline
Design
Editorial
Authors
Loading...
In a rabbit model of massive rivaroxaban overdose, rFVIIa and PCC improved coagulation parameters but failed to reduce actual bleeding, suggesting further studies at clinically relevant doses are needed.
Does rFVIIa or PCC reduce bleeding or normalize coagulation tests in a rabbit model of rivaroxaban overdose?
In a rabbit model of massive rivaroxaban overdose, rFVIIa and PCC improved coagulation parameters but failed to reduce actual bleeding, suggesting further studies at clinically relevant doses are needed.
Spahn et al. (2011) conducted an editorial in Bleeding associated with novel oral anticoagulants. Procoagulants (PCC and rFVIIa) for rivaroxaban reversal was evaluated. In an animal model of massive rivaroxaban overdose, administration of procoagulants like PCC and rFVIIa partially corrected coagulation test results but did not reduce clinical bleeding.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: