Key result
Intramuscular administration of ketorolac precipitated colonic ulceration, suggesting a role for the systemic effects of nonsteroidal antiinflammatory agents in gastrointestinal ulceration.
Why the study?
Does intramuscular administration of ketorolac cause colonic ulceration?
Does intramuscular administration of ketorolac cause colonic ulceration?
Highlights the potential for systemic NSAID administration to cause gastrointestinal ulceration.
May warrant vigilance for colonic ulceration after IM ketorolac; leaves open systemic NSAID contribution to GI injury.
We report the first case of colonic ulceration precipitated by the intramuscular administration of ketorolac. This report suggests a role for the systemic effects of nonsteroidal antiinflammatory agents in the development of gastrointestinal ulceration.
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Buchman et al. (1996) studied this question. Intramuscular administration of ketorolac precipitated colonic ulceration, suggesting a role for the systemic effects of nonsteroidal antiinflammatory agents in gastrointestinal ulceration.
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