Tracking of glycated hemoglobin in the original cohort of the framingham heart study
Key result
HbA1c demonstrates good long-term reliability in nondiabetic older adults with a modest ~0.3% increase.
- MD 0.28%
- P<0.0001
- n=639
Why the study?
The reliability and tracking of glycated hemoglobin A1c over several years in nondiabetic elderly individuals was not well established.
Population
639 elderly presumptively nondiabetic members of the original Framingham Heart Study cohort
Comparison
Baseline vs follow-up HbA1c measurements
Design
Cohort study
Follow-up
4 to 6 years
Authors
Discussion
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Member takes
Implication
Modest HbA1c rise in elderly nondiabetics warrants no practice change; leaves open whether tracking improves risk stratification.
Study Design
Type
Cohort (n=639)
Multicenter
No
Structured PICO
P
Population
639 elderly, presumptively nondiabetic members of the Framingham Heart Study cohort followed for 4 to 6 years.
O
Outcome
Tracking and reliability of HbA1c measurements over 4 to 6 yearssurrogate
Main Result
Mean Difference: 0.28
Absolute Event Rate: 5.71% vs 5.43%
p-value: p=< 0.0001
Glycated hemoglobin reliably categorizes the glucose control of nondiabetic subjects over a period of 4 to 6 years, confirming its value as an epidemiological measure.
Cite This Study
Meigs et al. (1996) conducted a cohort in Nondiabetic (n=639). HbA1c tracking over time vs. Baseline was evaluated on Change in HbA1c between baseline and follow-up (MD 0.28%, p=< 0.0001). HbA1c measurements in elderly nondiabetic subjects demonstrated good reliability over 4 to 6 years (intraclass correlation 0.59), with a modest mean increase of 0.28% (p < 0.0001).