Performance of serum amyloid A and C reactive protein for disease control assessment in familial Mediterranean fever

This is the authors' abstract. We don't add key points for this paper.

Familial Mediterranean fever (FMF) is a monogenic autoinflammatory disease responsible for periodic inflammatory flares. The most critical complication of FMF is AA amyloidosis.1 It is caused by the deposition of serum amyloid A (SAA) proteins in the organs due to repeated or chronic high levels of SAA.2 European recommendations for the treatment of FMF suggest that C-reactive protein (CRP) and SAA levels should be monitored.2,3 The assessment of disease control relies on both inflammatory markers and declared number of flares, which can be subjective.