Serology- and PCR-based cumulative incidence of SARS-CoV-2 infection in adults in a successfully contained early hotspot (CoMoLo study), Germany, May to June 2020

Claudia Hövener; Hannelore K. Neuhauser; Angelika Schaffrath Rosario; Markus Alexander Busch; Martin Schlaud; Robert G. Hoffmann; Antje Gößwald; Carmen Koschollek; Jens Hoebel; Jennifer Nancy Lee Allen; Antje Haack-Erdmann; Stefan Brockmann; Thomas Ziese; Andreas Nitsche; Janine Michel; Sebastian Haller; Hendrik Wilking; Osamah Hamouda; Victor M. Corman; Christian Drosten; Lars Schaade; Lothar Heinz Wieler

doi:10.2807/1560-7917.es.2020.25.47.2001752

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Abstract

Three months after a coronavirus disease (COVID-19) outbreak in Kupferzell, Germany, a population-based study (n = 2,203) found no RT-PCR-positives. IgG-ELISA seropositivity with positive virus neutralisation tests was 7.7% (95% confidence interval (CI): 6.5-9.1) and 4.3% with negative neutralisation tests. We estimate 12.0% (95% CI: 10.4-14.0%) infected adults (24.5% asymptomatic), six times more than notified. Full hotspot containment confirms the effectiveness of prompt protection measures. However, 88% naïve adults are still at high COVID-19 risk.

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synapsesocial.com/papers/6ab4ac5b5a9fa8d7444ddb5d https://doi.org/10.2807/1560-7917.es.2020.25.47.2001752

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Serology- and PCR-based cumulative incidence of SARS-CoV-2 infection in adults in a successfully contained early hotspot (CoMoLo study), Germany, May to June 2020

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Serology- and PCR-based cumulative incidence of SARS-CoV-2 infection in adults in a successfully contained early hotspot (CoMoLo study), Germany, May to June 2020

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