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Reveals persistent bile acid dysregulation and dyslipidemia in maternal and cord blood after UDCA therapy for pregnancy cholestasis, highlighting the need for targeted interventions.
This study uncovers that despite ursodeoxycholic acid treatment, intrahepatic cholestasis of pregnancy (ICP) is associated with increases in the ratio of cholic acid to chenodeoxycholic acid in both maternal and cord blood, suggesting ongoing dysregulation of bile acid metabolism. The high cholic to chenodeoxycholic acid ratio is correlated with maternal dyslipidemia and high cord blood lipids. These findings may inform more targeted approaches to managing ICP.
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Basu et al. (2025) studied this question.
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