Twenty-two young adult C3H/He male mice were exposed to 3Gy, preferable condition to induce myeloid leukemias, and another group of 22 males to the fractionated irradiation of 4×1.7Gy, preferable to lymphoid tumors. The stable type aberrations of chromosomes in bone marrow cells of those mice were analyzed within 3 months and in longer than 15 months after final irradiations in both groups. The mice exposed to 3Gy had cells with abnormal chromosome no. 2 more than those exposed to 4×1.7Gy did. The number of cells with chromosomal abnormalities in general increased at the late stage in the mice given 4×1.7Gy, but not in the mice received 3Gy. The chromosomes whose frequencies exceeded mean plus two times the value of standard deviation were the chromosome no. 2 in the former and the chromosome no. 11 in the latter.
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Hayata et al. (1987) studied this question.