Key result
Resveratrol reduces arthritis severity scores by ~60% versus normal diet in mice.
Why the study?
The potential of dietary supplementation with resveratrol to suppress joint inflammation and destruction in collagen-induced arthritis was investigated.
Does dietary supplementation with resveratrol suppress joint inflammation and destruction in a mouse model of collagen-induced arthritis?
Does dietary supplementation with resveratrol suppress joint inflammation and destruction in a mouse model of collagen-induced arthritis?
Absolute Event Rate: 2.7% vs 6.7%
p-value: p=<0.01
This preclinical study investigates the potential of dietary resveratrol to suppress joint inflammation and bone destruction in a mouse model of rheumatoid arthritis.
Supports further preclinical testing of resveratrol in arthritis; leaves open translation to human disease.
Objective. Resveratrol is well-known for its anti-inflammatory, anti-oxidant effects on several diseases. We investigated wheth-er dietary supplementation with resveratrol may suppress joint inflammation and destruction in a mouse model of collagen-in-duced arthritis (CIA). Methods. Mice were randomly divided into two groups; CIA mice with normal diet-fed and CIA mice fed a 0.05 % resveratrol diet. The effect of resveratrol on arthritis was assessed by clinical scoring system. The plain radiographs of paws were obtained to evaluate the effects on preventing bone destruction. Joint inflammation, cartilage damage, and osteo-clastic bone resorption were checked by staining with H&E, Safranin-O, and tartrate resistant acid phosphatase (TRAP). Levels of pro-inflammatory cytokines were checked by enzyme-linked immunosorbent assay. The level of expression of nuclear factor (NF)-κB was measured by electrophoretic mobility shift assay (EMSA). Results. Dietary supplementation with resveratrol led
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Cheon et al. (2015) studied Collagen-induced arthritis (Rheumatoid arthritis model) (n=20). Resveratrol dietary supplementation vs. Normal diet was evaluated on Severity of arthritis (clinical scoring system) (p=<0.01). Dietary supplementation with resveratrol significantly mitigated the severity of arthritis compared to a normal diet in a mouse model of collagen-induced arthritis (clinical score 2.7 vs 6.7).
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