Key result
Exposure of pregnant mice to 0.6% isoflurane significantly increased the incidence of cleft palate to 12.1% compared to 0.75% in controls, alongside decreased fetal weight and skeletal ossification.
Why the study?
Does isoflurane exposure during pregnancy cause developmental toxicity in mice?
Does isoflurane exposure during pregnancy cause developmental toxicity in mice?
Absolute Event Rate: 12.1% vs 0.75%
Light anesthetic exposure (0.6%) to isoflurane during pregnancy in mice causes significant developmental toxicity, including cleft palate and renal abnormalities.
Low-dose isoflurane shows no developmental toxicity in mice; leaves open human relevance and need for clinical data.
The developmental toxicity of trace (0.006%), subanesthetic (0.06%), and light anesthetic (0.6%) exposure to isoflurane was examined in Swiss/Webster mice. No adverse effects were demonstrated following exposure of dams to 0.006% (n = 26) and 0.06% (n = 27) isoflurane for 4 hr daily on days 6-15 of pregnancy. Exposure to 0.6% isoflurane (n = 23) for the same period resulted in significantly decreased fetal weight, decreased skeletal ossification, minor hydronephrosis, and increased renal pelvic cavitation. The incidence of cleft palate also was significantly increased, abnormalities occurring in 12.1% of fetuses and affecting 11 of 23 litters. This incidence was considerably higher than that of the combined treatment and colony control groups (0.75%) and those that we have found in previous experiments with this mouse strain following exposure to halothane (1.2%) or enflurane (1.9%).
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Mazze et al. (1985) studied Pregnancy (n=76). Isoflurane vs. Combined treatment and colony control groups was evaluated on Incidence of cleft palate. Exposure of pregnant mice to 0.6% isoflurane significantly increased the incidence of cleft palate to 12.1% compared to 0.75% in controls, alongside decreased fetal weight and skeletal ossification.
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