What question did this study set out to answer?

Characterize the progressive metabolic, biochemical, and transcriptional alterations that occur during c-Myc-driven hepatocellular carcinoma evolution, regression, and recurrence.

April 22, 2017Journal of Biological ChemistryOpen Access

Sequential adaptive changes in a c-Myc-driven model of hepatocellular carcinoma

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Authors

JDJames M. DolezalGeisinger Medical Center HWHuabo WangUniversity of Pittsburgh SKSucheta KulkarniTata Institute for Genetics and Society

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Implication

Animal study demonstrates distinct metabolic reprogramming and transcriptional shifts across liver tumor stages in mice, highlighting mechanisms driving cancer recurrence.

Key Points

Characterize the progressive metabolic, biochemical, and transcriptional alterations that occur during c-Myc-driven hepatocellular carcinoma evolution, regression, and recurrence.
Evaluated metabolic fluxes, mitochondrial mass, and electron transport chain respiration across tumor progression, regression, and recurrence in a Myc-induced mouse model of hepatocellular carcinoma.
Performed RNA sequencing to map dynamic transcriptional pathway changes across disease stages and established an interactive software tool to profile gene expression.
Initial tumors exhibited altered pyruvate and fatty acid β-oxidation, reduced mitochondrial mass, and uncoupled complex II activity that favored the production of reactive oxygen species.
RNA sequencing demonstrated sequential transcriptional alterations across DNA damage repair, cell cycle progression, and innate immunity, with recurrent tumors normalizing a subset of initial abnormalities.

Cite This Study

Dolezal et al. (2017) studied this question.

synapsesocial.com/papers/6ab4ba4a905fd2f77ff63e79 https://doi.org/10.1074/jbc.m117.782052

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Implication

Animal study demonstrates distinct metabolic reprogramming and transcriptional shifts across liver tumor stages in mice, highlighting mechanisms driving cancer recurrence.

Sequential adaptive changes in a c-Myc-driven model of hepatocellular carcinoma

Discussion

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Implication

Key Points

Cite This Study

Sequential adaptive changes in a c-Myc-driven model of hepatocellular carcinoma

Discussion

Member takes

Implication

Key Points

Cite This Study

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