Case report demonstrates successful resolution of multiply relapsed visceral leishmaniasis using combination therapy in an HIV-infected individual, highlighting the efficacy of dual regimens.
Visceral Leishmaniasis (VL) is an opportunistic infection amongst HIV-infected people in several endemic countries, and the clinical management of this co-infection poses several challenges. Here we describe a co-infected patient in India who failed to respond to miltefosine monotherapy and subsequently relapsed following two further (different) regimens of liposomal amphotericin B. He was then successfully treated with a combination of 30 mg/kg liposomal amphotericin B and 14 days of 100mg/day oral miltefosine.
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Patole et al. (2014) studied this question.
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