Key result
Age-related factors may alter the disposition, pharmacokinetics, and pharmacodynamics of cytotoxic chemotherapy drugs in elderly patients.
This review discusses age-related factors that alter the disposition and effects of cancer chemotherapy in older patients.
Clinicians should consider age-related PK/PD changes for chemotherapy dosing in older adults; leaves open optimal regimens pending prospective geriatric trials.
With more widespread use of effective chemotherapy, more elderly patients are candidates for treatment with cytotoxic drugs. This article reviews and discusses the relevant age-related factors that may alter drug disposition and its relationship to pharmacokinetics effects and to pharmacodynamic effects in the elderly.
No takes yet. Share an insight, caveat, or question.
Baker et al. (1997) studied this question. Age-related factors may alter the disposition, pharmacokinetics, and pharmacodynamics of cytotoxic chemotherapy drugs in elderly patients.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: