Key result
Clozapine is associated with QTc prolongation compared to non-users.
Why the study?
QTc prolongation associated with antipsychotic use is well documented and has led to market withdrawal of some agents, but specific data on clozapine are needed.
Antipsychotics, including clozapine, are associated with QTc prolongation, a known safety risk that has previously led to market withdrawals.
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Reinforces QTc monitoring caution with clozapine; confirms known association yet leaves open prospective validation.
Dhillon et al. (2011) studied this question. Clozapine use is associated with QTc prolongation, a well-documented adverse effect among antipsychotic medications.
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