Why the study?
Does clozapine treatment increase the prevalence of ECG abnormalities in patients with treatment-resistant schizophrenia?
Population
n=61 patients with treatment-resistant schizophrenia treated with clozapine at a single center
Comparison
Clozapine treatment vs Baseline status while on previous antipsychotics…
Design
Cohort
Authors
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May warrant ECG monitoring with clozapine; extends observational safety data but leaves randomized confirmation of clinical impact open.
Does clozapine treatment increase the prevalence of ECG abnormalities in patients with treatment-resistant schizophrenia?
While clozapine treatment increases the prevalence of ECG abnormalities and QTc prolongation in patients with treatment-resistant schizophrenia, these changes are mostly benign and do not typically require treatment discontinuation.
Kang et al. (2000) studied this question.
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