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January 10, 2005Journal of Clinical Psychopharmacology

Adverse Cardiac Effects Associated With Clozapine

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Why the study?

What are the serious adverse cardiac events associated with clozapine treatment?

Population

Patients taking or candidates for clozapine treatment

Design

Review

Authors

DMDavid B. MerrillGDG. William DecDGDonald Goff

Discussion

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Overview

Supports cardiac monitoring in clozapine users; leaves open precise QTc risks in comorbid patients.

Structured PICO

What are the serious adverse cardiac events associated with clozapine treatment?

P
Population
Patients taking or candidates for clozapine treatment
I
Intervention
Clozapine
O
Outcome
Serious adverse cardiac events (myocarditis, cardiomyopathy, cardiotoxicity, sudden death, or mortality)safety

Clozapine is associated with a low risk of fatal myocarditis or cardiomyopathy, necessitating appropriate cardiac assessment and monitoring before and during treatment.

Cite This Study

Merrill et al. (2005) studied this question.

synapsesocial.com/papers/6a708199f44fa9f079de2a89https://doi.org/10.1097/01.jcp.0000150217.51433.9f
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Myocarditis Related to Clozapine Treatment2001 · 142 citations
  2. 2Antipsychotic drugs and heart muscle disorder in international pharmacovigilance: data mining study2001 · 235 citations
  3. 3Effects of Newer Atypical Antipsychotics on Autonomic Neurocardiac Function: A Comparison Between Amisulpride, Olanzapine, Sertindole, and Clozapine2001 · 168 citations
  4. 4Antipsychotics and sudden death: Is thioridazine the only bad actor?2002 · 24 citations
  5. 5Tolerability and therapeutic effect of clozapine1985 · 281 citations