Why the study?
Does clozapine initiation increase the risk of cardiac adverse events such as myocarditis, pericarditis, and cardiomyopathy compared to other antipsychotics in out-patients?
Does clozapine initiation increase the risk of cardiac adverse events such as myocarditis, pericarditis, and cardiomyopathy compared to other antipsychotics in out-patients?
Cardiac adverse events such as myocarditis and cardiomyopathy are extremely rare in out-patients initiating clozapine and occur at rates comparable to other antipsychotic drugs.
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Clozapine cardiac monitoring may need refinement; leaves open true incidence and screening impact in broader populations.
Rohde et al. (2017) studied this question.
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