Why the study?
Does early treatment with clozapine impair left ventricular function in treatment-resistant schizophrenia patients?
Population
n=15 treatment-resistant schizophrenia patients, aged 18-55 years, without evidence of cardiovascular disease.
Comparison
Clozapine, dose increased from 25 to 100 mg/day… vs Baseline (pre-treatment assessment).
Design
Cohort
Follow-up
4 weeks
Authors
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Early cardiac monitoring may be considered with clozapine initiation; leaves open need for larger prospective trials.
Does early treatment with clozapine impair left ventricular function in treatment-resistant schizophrenia patients?
Early treatment with moderate doses of clozapine is associated with subclinical but substantial decreases in left ventricular systolic and diastolic function in patients without prior cardiovascular disease.
Curto et al. (2015) studied this question.
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