February 1, 2014Open HeartOpen Access

Asymptomatic left ventricular dysfunction with long-term clozapine treatment for schizophrenia: a multicentre cross-sectional cohort study

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Why the study?

Does long-term clozapine treatment cause subclinical left ventricular dysfunction in patients with schizophrenia?

Population

141 participants: 100 consecutive patients with schizophrenia treated with clozapine for >1 year without…

Comparison

Clozapine treatment for >1 year vs Non-clozapine antipsychotics for >1 year or no…

Design

Cross-sectional

Authors

VCVincent Chow TYThomas Yeoh ANA. Ng

Discussion

Member takes

Overview

Clozapine use was associated with subclinical LV impairment in schizophrenia; leaves open causality and need for prospective monitoring studies.

Structured PICO

Does long-term clozapine treatment cause subclinical left ventricular dysfunction in patients with schizophrenia?

Population

141 participants: 100 consecutive patients with schizophrenia treated with clozapine for >1 year without history of cardiac pathology, 21 controls with schizophrenia treated with non-clozapine antipsychotics for >1 year, and 20 healthy controls without schizophrenia.

Intervention

Clozapine treatment for >1 year (mean duration 6.8±5.3 years)

Comparator

Non-clozapine antipsychotics for >1 year (mean duration 9.7±6.1 years) or no schizophrenia (healthy controls)

Outcome

Subclinical cardiomyopathy assessed by left ventricular ejection fraction (LVEF) and global longitudinal strain (GLS)surrogate

Long-term clozapine treatment in schizophrenia is associated with asymptomatic mild left ventricular impairment, which correlates with neutrophilia and low HDL-C.

Cite This Study

Chow et al. (2014) studied this question.

synapsesocial.com/papers/6a7a645014b028facf0e5438 https://doi.org/10.1136/openhrt-2013-000030

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February 1, 2014Open HeartOpen Access

Asymptomatic left ventricular dysfunction with long-term clozapine treatment for schizophrenia: a multicentre cross-sectional cohort study

View Full Paper

Ask AI

Bookmark

Why the study?

Does long-term clozapine treatment cause subclinical left ventricular dysfunction in patients with schizophrenia?

Population

141 participants: 100 consecutive patients with schizophrenia treated with clozapine for >1 year without…

Comparison

Clozapine treatment for >1 year vs Non-clozapine antipsychotics for >1 year or no…

Design

Cross-sectional

Authors

VCVincent Chow TYThomas Yeoh ANA. Ng

Discussion

Member takes

Overview

Clozapine use was associated with subclinical LV impairment in schizophrenia; leaves open causality and need for prospective monitoring studies.

Structured PICO

Does long-term clozapine treatment cause subclinical left ventricular dysfunction in patients with schizophrenia?

Population

Intervention

Clozapine treatment for >1 year (mean duration 6.8±5.3 years)

Comparator

Non-clozapine antipsychotics for >1 year (mean duration 9.7±6.1 years) or no schizophrenia (healthy controls)

Outcome

Subclinical cardiomyopathy assessed by left ventricular ejection fraction (LVEF) and global longitudinal strain (GLS)surrogate

Long-term clozapine treatment in schizophrenia is associated with asymptomatic mild left ventricular impairment, which correlates with neutrophilia and low HDL-C.

Cite This Study

Chow et al. (2014) studied this question.

synapsesocial.com/papers/6a7a645014b028facf0e5438 https://doi.org/10.1136/openhrt-2013-000030

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

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