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Primary uterine lymphoma is rare. Diagnosis can be delayed due to unfamiliarity of treatment teams with the typical imaging appearance of gynecologic lymphoma. Although clinical symptoms overlap with those of other disease processes, imaging characteristics of primary gynecologic lymphoma, such as tumor homogeneity, preservation of uterine architecture, and uniform hypoenhancement, are often suggestive. Identification of key features that suggest the diagnosis on imaging can help guide the pathologist, as biopsy diagnosis can be difficult. Unlike other gynecologic cancers, lymphoma is treated nonsurgically. Delaying diagnosis until hysterectomy can postpone needed chemoradiation for months pending recovery. We present a case of primary uterine lymphoma showing typical imaging findings on MRI that, combined with confirmatory biopsy, prevented an unnecessary pelvic resection.
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Shah et al. (2025) studied this question.
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