Key result
An ultrasensitive real-time PCR assay did not detect occult hepatitis C virus infection in peripheral blood mononuclear cells of patients with cryptogenic liver diseases or systemic vasculitis.
Why the study?
Can occult hepatitis C virus infection be detected in peripheral blood mononuclear cells of patients with cryptogenic liver diseases or systemic vasculitis using an ultrasensitive real-time PCR assay?
Observational
Can occult hepatitis C virus infection be detected in peripheral blood mononuclear cells of patients with cryptogenic liver diseases or systemic vasculitis using an ultrasensitive real-time PCR assay?
Ultrasensitive real-time PCR assay did not detect occult HCV infection in peripheral blood mononuclear cells of patients with cryptogenic liver diseases or connective tissue diseases, questioning the significance of this entity in these populations.
No occult HCV detected by ultrasensitive PCR in these groups; leaves open its clinical relevance and requires prospective validation.
Occult hepatitis C infection is regarded as a new entity that should be considered when diagnosing patients with a liver disease of unknown origin. Using an ultrasensitive real-time PCR assay, we demonstrated that occult hepatitis C virus (HCV) infection cannot be found in peripheral blood mononuclear cells of patients with cryptogenic liver diseases, HCV--associated systemic vasculitis, or connective tissue diseases. The significance of such occult infection must be elucidated.
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Halfon et al. (2008) conducted an observational in Cryptogenic liver diseases, HCV-associated systemic vasculitis, or connective tissue diseases. Ultrasensitive real-time PCR assay was evaluated on Detection of occult hepatitis C virus infection in peripheral blood mononuclear cells. An ultrasensitive real-time PCR assay did not detect occult hepatitis C virus infection in peripheral blood mononuclear cells of patients with cryptogenic liver diseases or systemic vasculitis.
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