What is the clinical evidence from this study?

Study design: Review. Population: Virus-host membrane interactions. Intervention: Physicochemical tools (QCM-D, SPR, DFS, TIRF).

September 6, 2021Analytical and Bioanalytical ChemistryOpen Access

Physicochemical tools for studying virus interactions with targeted cell membranes in a molecular and spatiotemporally resolved context

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Key result

Emerging physicochemical tools such as QCM-D, SPR, DFS, and TIRF microscopy provide molecular and spatiotemporally resolved insights into the complex mechanisms of virus binding and entry into cells.

Population

Model viruses and cell membrane mimics

Design

Review

Authors

MBMarta BallyCentre for Biomedical Engineering and Physics SBStephan BlockFreie Universität Berlin FHFredrik HöökInstitute of Biophysics

Discussion

Member takes

Overview

Bioanalytical insights remain preclinical; leaves open translation to clinically effective viral entry inhibitors.

Structured PICO

Population

Model viruses (simian virus 40, human norovirus, influenza A virus, human herpes simplex virus, human immunodeficiency virus type 1) and cell membrane mimics (supported lipid bilayers, live cells)

Intervention

Bioanalytical techniques including surface plasmon resonance (SPR), quartz crystal microbalance with dissipation (QCM-D), dynamic force spectroscopy (DFS), total internal reflection fluorescence (TIRF) microscopy combined with equilibrium fluctuation analysis (EFA) and single particle tracking (SPT), and confocal microscopy

Outcome

Quantification of binding strengths, residence times, diffusion characteristics, and binding kinetics of virus interactions with host cell surfaces

Emerging physicochemical tools provide spatiotemporally resolved insights into virus-host membrane interactions, which may aid in developing viral entry inhibitors.

Cite This Study

Bally et al. (2021) conducted a review in Virus-host membrane interactions. Physicochemical tools (QCM-D, SPR, DFS, TIRF) was evaluated. Emerging physicochemical tools such as QCM-D, SPR, DFS, and TIRF microscopy provide molecular and spatiotemporally resolved insights into the complex mechanisms of virus binding and entry into cells.

synapsesocial.com/papers/6ab4cb07503073f3cb75c86d https://doi.org/10.1007/s00216-021-03510-5

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September 6, 2021Analytical and Bioanalytical ChemistryOpen Access

Physicochemical tools for studying virus interactions with targeted cell membranes in a molecular and spatiotemporally resolved context

View Full Paper

Ask AI

Bookmark

Key result

Emerging physicochemical tools such as QCM-D, SPR, DFS, and TIRF microscopy provide molecular and spatiotemporally resolved insights into the complex mechanisms of virus binding and entry into cells.

Population

Model viruses and cell membrane mimics

Design

Review

Authors

MBMarta BallyCentre for Biomedical Engineering and Physics SBStephan BlockFreie Universität Berlin FHFredrik HöökInstitute of Biophysics

Discussion

Member takes

Overview

Bioanalytical insights remain preclinical; leaves open translation to clinically effective viral entry inhibitors.

Structured PICO

Population

Model viruses (simian virus 40, human norovirus, influenza A virus, human herpes simplex virus, human immunodeficiency virus type 1) and cell membrane mimics (supported lipid bilayers, live cells)

Intervention

Outcome

Quantification of binding strengths, residence times, diffusion characteristics, and binding kinetics of virus interactions with host cell surfaces

Emerging physicochemical tools provide spatiotemporally resolved insights into virus-host membrane interactions, which may aid in developing viral entry inhibitors.

Cite This Study

synapsesocial.com/papers/6ab4cb07503073f3cb75c86d https://doi.org/10.1007/s00216-021-03510-5

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