Key result
Severe IPAH is linked to elevated adipokines, higher endothelin-1, and osteoporosis in ~50% of patients.
Why the study?
The role of adipokines and vascular remodeling in the formation of osteoporosis in idiopathic pulmonary arterial hypertension was not well understood.
Observational (n=57)
Adipokine and endothelin dysregulation may play a role in the development of hemodynamic disorders and osteopenic syndrome in patients with severe idiopathic pulmonary arterial hypertension.
Osteoporosis screening may be considered in severe IPAH; hypothesis-generating for adipokine contributions to bone loss.
PURPOSE: to determine the role of adipokines and vascular remodeling in formation of osteoporosis in idiopathic pulmonary arterial hypertension (IPAH). MATERIALS AND METHODS: Functional and hemodynamic parameters, bone mineral density (BMD) T-score in lumbar spine (LS) and femoral neck (FN), blood serum levels of leptin, adiponectin, visfatin and endothelin-1 were measured in 27 patients with severe IPAH and 30 healthy volunteers. RESULTS: Half of IPAH patients had osteoporosis. Serum levels of leptin, adiponectin, visfatin and endothelin-1 in IPAH group were higher than in healthy volunteers. BMD T-score was directly related to results of 6‑minute walk test and inversely related to pulmonary vascular resistance (PVR). Circulating adiponectin and visfatin concentrations correlated with PVR; endothelin-1 concentration was directly related to pulmonary arterial systolic pressure, cardiac index and PVR. Relations between BMD T-score and circulating adiponectin, visfatin, and endothelin-1 were inverse. Positive correlations existed between serum adiponectin, visfatin and endothelin-1 levels. CONCLUSION: Results of our study confirm the important role of adipokine and endotheline dysregulation in development of hemodynamic disorders in severe IPAH and evidence for their possible involvement in formation of osteopenic syndrome.
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Kochetkova et al. (2018) conducted an observational in Idiopathic pulmonary arterial hypertension (n=57). Severe idiopathic pulmonary arterial hypertension vs. Healthy volunteers was evaluated on Bone mineral density T-score and serum levels of leptin, adiponectin, visfatin and endothelin-1. Severe idiopathic pulmonary arterial hypertension was associated with elevated serum adipokines and endothelin-1 compared to healthy volunteers, and 50% of IPAH patients had osteoporosis.
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