Key result
Quilty lesions linked to higher acute cellular rejection rates of ~93% without altering survival.
Why the study?
The clinical significance of Quilty lesions in endomyocardial biopsies of cardiac transplantation patients was unclear.
Cohort (n=117)
No
Quilty lesions in endomyocardial biopsies after heart transplantation are associated with previous acute cellular rejection and cardiac allograft vasculopathy, but do not appear to impact overall patient survival.
Answers are grounded in this paper and cite their sources.
Quilty lesions were associated with higher rejection and vasculopathy rates but not survival; leaves open whether they should alter biopsy surveillance in heart transplant recipients.
BACKGROUND: The aim of this study was to investigate the clinical significance of Quilty lesions in endomyocardial biopsies (EMBs) of cardiac transplantation patients. METHODS: A total of 1190EMBs from 117 cardiac transplantation patients were evaluated histologically for Quilty lesions,acute cellular rejection, and antibody-mediated rejection. Cardiac allograft vasculopathy wasdiagnosed by computed tomography coronary angiography. Clinical information, including thepatients' survival was retrieved by a review of medical records. RESULTS: Eighty-eight patients(75.2%) were diagnosed with Quilty lesions, which were significantly associated with acute cellularrejection, but not with acute cellular rejection ≥ 2R or antibody-mediated rejection. In patientsdiagnosed with both Quilty lesions and acute cellular rejection, the time-to-onset of Quilty lesionsfrom transplantation was longer than that of acute cellular rejections. We found a significant associationbetween Quilty lesions and cardiac allograft vasculopathy. No significant relationship wasfound between Quilty lesions and the patients' survival. CONCLUSIONS: Quilty lesion may be an indicator of previous acute cellular rejection rather than a predictor for future acute cellular rejection.
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Cho et al. (2018) conducted a cohort in Cardiac transplantation (n=117). Quilty lesions vs. Absence of Quilty lesions was evaluated on Any acute cellular rejection (p=0.006). The presence of Quilty lesions in endomyocardial biopsies was significantly associated with a higher incidence of any acute cellular rejection (93.2% vs 72.4%) and cardiac allograft vasculopathy, but not with patient survival.
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