In this study, T. Chen and co-workers present a cancer-targeted MSN drug-delivery system carrying ruthenium complexes (RuPOP@MSNs), that allows the direct fluorescence monitoring of the cellular uptake and localization of theranostic agents in cancer cells. On page 2754 the nanoparticles exhibit unprecedented enhanced cytotoxicity toward cancer cells overexpressing integrin receptors through the induction of apoptosis. Moreover, the strong autofluorescence of Ru complex extends the power of theranostics to a subcellular level.
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He et al. (2014) studied this question.
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