Key result
Naltrexone precipitates acute MI during methadone maintenance via severe opioid withdrawal.
Why the study?
The cardiovascular effects of opioid withdrawal and the potential for myocardial infarction following naltrexone consumption in patients on methadone maintenance therapy are not well characterized.
Does naltrexone consumption precipitate myocardial infarction in patients on methadone maintenance therapy?
Case Report (n=1)
Does naltrexone consumption precipitate myocardial infarction in patients on methadone maintenance therapy?
Naltrexone consumption in patients on methadone maintenance therapy may precipitate opioid withdrawal syndrome leading to acute myocardial infarction.
Raises caution for MI risk with naltrexone in methadone patients; case report leaves causal association open for confirmation.
Cardiovascular effects of opioid withdrawal have long been studied. It was reported that patients with underlying ischemic heart disease and atherosclerotic vessels may be complicated by a sudden physical and emotional stress due to withdrawal syndrome. But some other believes sudden increase in catecholamine level as a sympathetic overflow might effect on heart with and without underlying ischemia. In the current study, a patient on methadone maintenance therapy (MMT) who experienced myocardial infarction (MI) after taking naltrexone was described.
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Dadpour et al. (2017) conducted a case report in Acute Myocardial Infarction (n=1). Naltrexone was evaluated on Myocardial infarction. Naltrexone consumption in a patient on methadone maintenance therapy precipitated an acute myocardial infarction, highlighting the cardiovascular risks of opioid withdrawal.
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