Key result
Experimental models evaluate collateral pressure and flow changes after internal mammary artery ligation.
Why the study?
Progress in the surgical therapy of arteriosclerotic heart disease has remained relatively stationary despite many procedures, motivating study of hemodynamic principles in internal mammary artery ligation.
Does internal mammary artery ligation increase blood flow through collateral channels in an experimental model?
Does internal mammary artery ligation increase blood flow through collateral channels in an experimental model?
This experimental study aims to evaluate the hemodynamic rationale for internal mammary artery ligation as a treatment for arteriosclerotic heart disease.
Experimental hemodynamic models link fluid dynamics to atherosclerotic sites; leaves open translation to coronary surgical therapy.
Although the surgical treatment of congenital and rheumatic heart disease has undergone remarkable expansion and refinement during the past 12 years, progress in the surgical therapy of arteriosclerotic heart disease has remained relatively stationary. The employment of at least 15 different surgical procedures for the treatment of this condition bears witness to the inconclusive results.1-9 This presentation concerns an attempt to study basic hemodynamic principles as they apply to experimental internal mammary artery ligation. Experimental methods were developed to gain information concerning the pressure and flow relationships in the internal mammary-pericardiophrenic artery system which would demonstrate whether the surgical procedure under investigation could logically be expected to increase blood flow through the desired channels. The existence of these channels has been known for many years and has been confirmed by injection studies.8Only recently has an attempt been made to utilize them as collateral routes for the purpose
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Rodman E. Taber (1958) studied Arteriosclerotic heart disease. Experimental internal mammary artery ligation was evaluated on Pressure and flow relationships in the internal mammary-pericardiophrenic artery system. Experimental methods were developed to study pressure and flow relationships following internal mammary artery ligation to determine if it increases blood flow through collateral channels.
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