May 28, 1959New England Journal of Medicine
An Evaluation of Internal-Mammary-Artery Ligation by a Double-Blind Technic
Key result
Bilateral internal-mammary-artery ligation was evaluated for the relief of angina pectoris using a double-blind technique, as its physiologic basis and effect on coronary flow remain unclear.
Authors
Discussion
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Implication
Double-blind RCT of internal-mammary-artery ligation underscores need for sham controls in angina procedures; challenges adoption of interventions lacking proven physiologic effect.
Study Design
Type
RCT
Blinding
Double-blind
PICO
P
Population
Angina pectoris
I
Intervention / Comparator
Bilateral internal-mammary-artery ligation
Limitations
- Definitely increased coronary flow after bilateral internal-mammary-artery ligation has not been shown
- The procedure does not afford protection to dogs after ligation
Cite This Study
Cobb et al. (1959) conducted an RCT in Angina pectoris. Bilateral internal-mammary-artery ligation was evaluated. Bilateral internal-mammary-artery ligation was evaluated for the relief of angina pectoris using a double-blind technique, as its physiologic basis and effect on coronary flow remain unclear.