Key result
Internal mammary artery implantation decreased angina in 75% of patients and reduced the rate of reinfarction by 50% compared to controls over up to 48 months of follow-up.
Why the study?
Does myocardial revascularization with internal mammary artery implantation reduce angina and reinfarction in patients with coronary disease?
Cohort (n=100)
Does myocardial revascularization with internal mammary artery implantation reduce angina and reinfarction in patients with coronary disease?
Answers are grounded in this paper and cite their sources.
Internal mammary artery implantation is effective in decreasing angina and reducing reinfarction rates in appropriately selected patients.
Objective criteria to indicate efficacy of revascularization have been defined in a series of 100 patients followed up to 48 months. Angina was decreased in 75% of the patients. Rate of reinfarction was reduced 50% when compared to control patients, but life expectancy was less clearly affected. The gains of this operation presumably take place after the neovascular connections between the implanted artery and the coronary circulation are established. Factors favoring successful revascularition are (1) a major degree of arterial obstruction, (2) local collateral formation, and (3) myocardial lactate production. Angina pectoris is the major indication for surgery. Surgery is contraindicated by severe heart failure, widespread atherosclerosis, or poor general health. Severe proximal coronary disease constitutes an augmented although not a prohibitive risk to surgery.
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Richard Gorlin (1969) conducted a cohort in Angina pectoris / Coronary artery disease (n=100). Myocardial revascularization with internal mammary artery implantation vs. Control patients was evaluated on Efficacy of revascularization (angina decrease and reinfarction rate). Internal mammary artery implantation decreased angina in 75% of patients and reduced the rate of reinfarction by 50% compared to controls over up to 48 months of follow-up.
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