Key result
Larger ascending aortic diameter is linked to ~4-fold higher odds of hypertension in men.
Why the study?
The association between ascending aortic diameter measured by low-dose chest CT and hypertension in Korean men was not well established.
Is ascending aortic diameter associated with hypertension in Korean men?
Cross-Sectional (n=1,050)
No
Is ascending aortic diameter associated with hypertension in Korean men?
Larger ascending aortic diameter measured on screening low-dose chest CT is independently associated with a higher prevalence of hypertension in Korean men.
AAD on LDCT correlates with hypertension in Korean men; hypothesis-generating and requires prospective validation before clinical use.
PURPOSE: The purpose of this study was to evaluate the association between ascending aortic diameter (AAD) as measured with low-dose chest computed tomography (LDCT) and hypertension in Korean men. METHODS: Korean men (n=1,050) who were screened for lung cancer using LDCT imaging at a health promotion center in Seoul, Korea between January 1 and December 31were recruited for the study. AAD is the longest length of ascending aorta measured from approximately 15 mm above left main coronary ostium to the mid-slice level of the right pulmonary artery. RESULTS: AAD were divided into quartiles, and the degree of hypertension was determined based on the quartiles of the AAD using logistic regression. Odds ratios (OR) for the proportion of hypertension in Q2 (1.70, 95% CI: 1.11-2.59), Q3 (2.72, 95% CI: 1.81-4.09) and Q4 (3.94, 95% CI: 2.63-5.89) were significantly greater than that of Q1 (P for trend < 0.001). Even after controlling for confounding covariates of age, BMI, total cholesterol, HDL-cholesterol, fasting glucose, GGT, ALT, eGFR, smoking status and alcohol intake, there was significant correlation. CONCLUSION: AAD was significantly associated with the degree of hypertension.
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Suh et al. (2017) conducted a cross-sectional in Hypertension (n=1,050). Ascending aortic diameter (highest quartile) vs. Lowest quartile of ascending aortic diameter was evaluated on Hypertension (OR 3.94, 95% CI 2.63-5.89, p=< 0.001). Ascending aortic diameter was significantly associated with hypertension in Korean men, with the highest quartile having an odds ratio of 3.94 (95% CI 2.63-5.89) compared to the lowest quartile.
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