Why the study?
The mechanisms underlying hepatic cholesterol accumulation with insulin resistance and its role in the pathogenesis of NASH were unclear.
Does dietary cholesterol and hyperinsulinemia drive hepatic accumulation of free cholesterol and transition to NASH in a mouse model?
Does dietary cholesterol and hyperinsulinemia drive hepatic accumulation of free cholesterol and transition to NASH in a mouse model?
In obese, diabetic mice, hyperinsulinemia alters cholesterol homeostasis leading to hepatic free cholesterol accumulation, which mediates the transition from steatosis to NASH.
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Rooyen et al. (2012) studied Nonalcoholic steatohepatitis (NASH) and Type 2 diabetes. High-fat diets with varying percentages of cholesterol vs. Diets without cholesterol and wild-type mice was evaluated on Hepatic lipid pools and pathways of cholesterol turnover.
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